Minervino Murge was inhabited since prehistory. The first primitive settlement probably dates back to the VIII and VII century A.D.
Beginning from the III A.D. all tracks have been lost until the early Middle Ages. Repeatedly destroyed by saracen invasions  and Byzantine reprisals, the village was bishop's see during the Norman Age untill 1818, and then county capital. In the XV century the village became the rule of the Princes of Taranto and then feud of some noble families, such as the Del Tufo, Pignatelli, Carafa and  Tuttavilla that kept the feud until the feudalism’s abolition. The “Scesciola” i.e. the oldest core of the village, is characterized by a labyrinth of narrow streets, slopes, and modest houses with lime walls. They rise on the hillside, being built one next to each other by means of little arches. Moreover, many holy niches are evidence of a deep faith. Today, the “Scesciola” is poorly inhabited, but still has its original architectonic characteristics; this is the reason why the reconstruction of the buildings history is currently possible.